Radiosynthesis and in Vivo Evaluation of [11C]MPC-6827, the First Brain Penetrant Microtubule PET Ligand-Reference-Cited by-同舟云学术

Radiosynthesis and in Vivo Evaluation of [11C]MPC-6827, the First Brain Penetrant Microtubule PET Ligand

Published:2018-02-19 Issue:5 Volume:61 Page:2118-2123
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kumar J. S. Dileep¹^ORCID,Solingapuram Sai Kiran Kumar²,Prabhakaran Jaya¹³,Oufkir Hakeem R.²,Ramanathan Gayathri²,Whitlow Christopher T.²,Dileep Hima¹³,Mintz Akiva²,Mann J. John¹³

Affiliation:

1. Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute, 1051 Riverside Drive, New York, New York 10032, United States

2. Department of Radiology, Wake Forest Medical Center, Winston Salem, North Carolina 27157, United States

3. Department of Psychiatry, Columbia University Medical Center, New York, New York 10032, United States

Funder

National Center for Advancing Translational Sciences

Diane Goldberg Foundation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00028

Reference40 articles.

1. The tubulin code: Molecular components, readout mechanisms, and functions

2. Structural Insights into Microtubule Function

3. Microtubule-Targeting Agents Enter the Central Nervous System (CNS): Double-edged Swords for Treating CNS Injury and Disease

4. The cytoskeleton as a novel therapeutic target for old neurodegenerative disorders

5. Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs

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