Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole Derivatives as Antiprotozoal Agents

Author:

Saccoliti Francesco1,Madia Valentina Noemi1,Tudino Valeria1,De Leo Alessandro1,Pescatori Luca1,Messore Antonella1ORCID,De Vita Daniela1,Scipione Luigi1,Brun Reto2,Kaiser Marcel2,Mäser Pascal2ORCID,Calvet Claudia M.34,Jennings Gareth K.3,Podust Larissa M.3,Pepe Giacomo5,Cirilli Roberto6ORCID,Faggi Cristina7ORCID,Di Marco Annalise8,Battista Maria Rosaria8,Summa Vincenzo8,Costi Roberta1,Di Santo Roberto1ORCID

Affiliation:

1. Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, “Sapienza” Università di Roma, p. le Aldo Moro 5, I-00185 Rome, Italy

2. Swiss Tropical and Public Health Institute, Socinstrasse 57, CH-4002 Basel, Switzerland

3. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States

4. Laboratório de Ultraestrutura Celular, Instituto Oswaldo Cruz (IOC), FIOCRUZ, Rio de Janeiro, Rio de Janeiro 21040-360, Brazil

5. Dipartimento di Farmacia, Università di Salerno, Via Giovanni Paolo II 132, I-84084 Fisciano, Salerno, Italy

6. Centro Nazionale per il Controllo e la Valutazione dei Farmaci, Istituto Superiore di Sanita, Viale Regina Elena 299, I-00161 Rome, Italy

7. Dipartimento di Chimica, Università degli studi di Firenze, Via della Lastruccia 13, I-50019, Sesto Fiorentino, Florence, Italy

8. Drug Discovery, IRBM Science Park, Via Pontina km 30,600, Pomezia, Rome 00071, Italy

Funder

Sapienza Università di Roma

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference70 articles.

1. Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

2. WHO. Fact sheets malaria. http://www.who.int/news-room/fact-sheets/detail/malaria (accessed July 3, 2018).

3. Neglected Tropical Diseases: Multi-Target-Directed Ligands in the Search for Novel Lead Candidates against Trypanosoma and Leishmania

4. Trypanosomatidae Diseases: From the Current Therapy to the Efficacious Role of Trypanothione Reductase in Drug Discovery

5. WHO. Neglected tropical diseases. http://www.who.int/neglected_diseases/diseases/en/ (accessed July 3, 2018).

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