Constraining Endomorphin-1 by β,α-Hybrid Dipeptide/Heterocycle Scaffolds: Identification of a Novel κ-Opioid Receptor Selective Partial Agonist-Reference-Cited by-同舟云学术

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Constraining Endomorphin-1 by β,α-Hybrid Dipeptide/Heterocycle Scaffolds: Identification of a Novel κ-Opioid Receptor Selective Partial Agonist

Published:2018-06-14 Issue:13 Volume:61 Page:5751-5757
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

De Marco Rossella¹,Bedini Andrea²,Spampinato Santi²,Comellini Lorenzo¹,Zhao Junwei¹,Artali Roberto³^ORCID,Gentilucci Luca¹^ORCID

Affiliation:

1. Department of Chemistry “G. Ciamician”, University of Bologna, Via Selmi 2, 40126 Bologna, Italy

2. Department of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy

3. Scientia Advice, 20832 Desio, Monza and Brianza, Italy

Funder

Universit? di Bologna

Fondazione Umberto Veronesi

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00296

Reference46 articles.

1. A potent and selective endogenous agonist for the µ-opiate receptor

2. The effects of endomorphin-1 and endomorphin-2 in CHO cells expressing recombinant μ-opioid receptors and SH-SY5Y cells

3. The Endomorphin System and Its Evolving Neurophysiological Role

4. Opioid peptides: potential for drug development

5. Recent Advances in Endomorphin Engineering

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1. Identification of c[D-Trp-Phe-β-Ala-β-Ala], the First κ-Opioid Receptor-Specific Negative Allosteric Modulator;ACS Pharmacology & Translational Science;2024-09-11

2. Conorphin-66 produces peripherally restricted antinociception via the kappa-opioid receptor with limited side effects;Neuropharmacology;2024-09

3. Harnessing the 1,3-azadiene-anhydride reaction for the regioselective and stereocontrolled synthesis of lactam-fused bromotetrahydropyrans by bromoetherification of lactam-tethered trisubstituted tertiary alkenols;RSC Advances;2024

4. Development of a Selective Peptide κ-Opioid Receptor Antagonist by Late-Stage Functionalization with Cysteine Staples;Journal of Medicinal Chemistry;2023-08-26

5. Design of κ-Opioid Receptor Agonists for the Development of Potential Treatments of Pain with Reduced Side Effects;Molecules;2023-01-01

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