Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents-Reference-Cited by-同舟云学术

Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents

Published:2018-10-18 Issue:22 Volume:61 Page:9908-9930
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Xiao-Ru¹,Wang Hao-Wen¹,Tang Wen-Lin¹,Zhang Yu¹,Yang Hui¹,Hu De-Xuan¹,Ravji Azhar²,Marchand Christophe²,Kiselev Evgeny²,Ofori-Atta Kwabena²,Agama Keli²,Pommier Yves²,An Lin-Kun¹^ORCID

Affiliation:

1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China

2. Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States

Funder

National Cancer Institute

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00639

Reference90 articles.

1. A Model for the Mechanism of Human Topoisomerase I