Discovery of Indolo[3,2-<i>c</i>]isoquinoline Derivatives as Novel Top1/2 Dual Inhibitors with Orally Efficacious Antitumor Activity and Low Toxicity-Reference-Cited by-同舟云学术

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Discovery of Indolo[3,2-c]isoquinoline Derivatives as Novel Top1/2 Dual Inhibitors with Orally Efficacious Antitumor Activity and Low Toxicity

Published:2024-08-06 Issue:16 Volume:67 Page:14155-14174
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Bichuan¹^ORCID,Wu Shanchao²,Jia Shuolei¹,Ruan Xiuqin¹,Sheng Chunquan²^ORCID,Zhou Qingfa¹^ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, China

2. The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Second Military Medical University (Naval Medical University), Shanghai 200433, China

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00982

Reference43 articles.

1. DNA Topoisomerases

2. DNA topoisomerases: harnessing and constraining energy to govern chromosome topology

3. Human topoisomerases and their roles in genome stability and organization

4. Optimization of the Natural Product Calothrixin A to Discover Novel Dual Topoisomerase I and II Inhibitors with Improved Anticancer Activity

5. Topoisomerase I protein expression in primary colorectal cancer and lymph node metastases

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