Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae-Reference-Cited by-同舟云学术

Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae

Published:2018-11-19 Issue:23 Volume:61 Page:10910-10921
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Friggeri Laura¹,Hargrove Tatiana Y.¹,Rachakonda Girish²,Blobaum Anna L.³,Fisher Paxtyn⁴,de Oliveira Gabriel Melo⁵,da Silva Cristiane França⁵,Soeiro Maria de Nazaré C.⁵,Nes W. David⁴,Lindsley Craig W.³^ORCID,Villalta Fernando²,Guengerich F. Peter¹^ORCID,Lepesheva Galina I.¹⁶^ORCID

Affiliation:

1. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States

2. Department of Microbiology, Immunology and Physiology, Meharry Medical College, Nashville, Tennessee 37208, United States

3. Vanderbilt Center for Neuroscience Drug Discovery, Franklin, Tennessee 37067, United States

4. Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409, United States

5. Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ 21040-360, Brazil

6. Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232, United States

Funder

Minist?rio da Ci?ncia, Tecnologia e Inova??o

U.S. Department of Health and Human Services

Fundacao Carlos Chagas Filho de Amparo ? Pesquisa do Estado do Rio de Janeiro

Fundacao Oswaldo Cruz

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01671

Reference48 articles.

1. Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease

2. Antiproliferative Effects and Mechanism of Action of SCH 56592 against Trypanosoma ( Schizotrypanum ) cruzi : In Vitro and In Vivo Studies

3. Cure of Short- and Long-Term Experimental Chagas' Disease Using D0870

4. Successful Treatment with Posaconazole of a Patient with Chronic Chagas Disease and Systemic Lupus Erythematosus

5. CYP51 as drug targets for fungi and protozoan parasites: past, present and future

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