Identification of Potent and Selective Inhibitors of <i>Acanthamoeba</i>: Structural Insights into Sterol 14α-Demethylase as a Key Drug Target-Reference-Cited by-同舟云学术

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Identification of Potent and Selective Inhibitors of Acanthamoeba: Structural Insights into Sterol 14α-Demethylase as a Key Drug Target

Published:2024-04-29 Issue:9 Volume:67 Page:7443-7457
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hargrove Tatiana Y.¹,Lamb David C.²,Wawrzak Zdzislaw³,Hull Marcus²,Kelly Steven L.²,Guengerich F. Peter¹^ORCID,Lepesheva Galina I.¹⁴⁵^ORCID

Affiliation:

1. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States

2. Faculty of Medicine, Health and Life Science, Swansea University, Swansea SA2 8PP, U.K.

3. Synchrotron Research Center, Life Science Collaborative Access Team, Northwestern University, Argonne, Illinois 60439, United States

4. Vanderbilt Institute of Chemical Biology, Nashville, Tennessee 37232, United States

5. Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232, United States

Funder

Medical Research Council

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00303

Reference81 articles.

1. Acanthamoeba spp. as a universal host for pathogenic microorganisms: One bridge from environment to host virulence

2. Environmental (Saprozoic) Pathogens of Engineered Water Systems: Understanding Their Ecology for Risk Assessment and Management

3. An update onAcanthamoebakeratitis: diagnosis, pathogenesis and treatment

4. Successful Treatment of DisseminatedAcanthamoebasp. Infection with Miltefosine

5. Granulomatous amoebic encephalitis: ghost response of an immunocompromised host?

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