Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action-Reference-Cited by-同舟云学术

Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action

Published:2018-10-04 Issue:23 Volume:61 Page:10619-10634
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Han Xingchun,Zhou Chengang,Jiang Min,Wang Yongguang,Wang Jianhua,Cheng Zhanling,Wang Min,Liu Yongqiang,Liang Chungen,Wang Jianping,Wang Zhanguo,Weikert Robert,Lv Wenzhe,Xie Jianxun,Yu Xin,Zhou Xue,Luangsay Souphalone,Shen Hong C.^ORCID,Mayweg Alexander V.,Javanbakht Hassan,Yang Song^ORCID

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01245

Reference19 articles.

1. WHO Hepatitis B Fact Sheet; World Health Organization: Geneva, July 18, 2018; http://www.who.int/en/news-room/fact-sheets/detail/hepatitis-b.

2. How chronic viral infections impact on antigen-specific T-cell responses

3. Clearing Persistent Extracellular Antigen of Hepatitis B Virus: An Immunomodulatory Strategy To Reverse Tolerance for an Effective Therapeutic Vaccination

4. CD40 Activation Rescues Antiviral CD8+ T Cells from PD-1-Mediated Exhaustion

5. Effective intrahepatic CD8+ T-cell immune responses are induced by low but not high numbers of antigen-expressing hepatocytes

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