The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity-Reference-Cited by-同舟云学术

The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity

Published:2017-12-22 Issue:1 Volume:61 Page:119-139
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Košak Urban¹,Brus Boris¹,Knez Damijan¹,Žakelj Simon¹,Trontelj Jurij¹,Pišlar Anja¹,Šink Roman¹,Jukič Marko¹,Živin Marko²,Podkowa Adrian³,Nachon Florian⁴^ORCID,Brazzolotto Xavier⁴,Stojan Jure⁵,Kos Janko¹,Coquelle Nicolas⁶,Sałat Kinga³,Colletier Jacques-Philippe⁶,Gobec Stanislav¹^ORCID

Affiliation:

1. Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia

2. Institute of Pathological Physiology, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia

3. Faculty of Pharmacy, Jagiellonian University, Medyczna 9 St., 30-688 Krakow, Poland

4. Institut de Recherche Biomédicale des Armées, 91223 Brétigny sur Orge, France

5. Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia

6. University Grenoble Alpes, and CNRS and CEA, IBS, F-38044 Grenoble, France

Funder

Agence Nationale de la Recherche

Javna Agencija za Raziskovalno Dejavnost RS

Association France Alzheimer

Commissariat ? l'?nergie Atomique et aux ?nergies Alternatives

Institut Francais

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01086

Reference89 articles.

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