Facile Synthesis, Geometry, and 2′-Substituent-Dependent in Vivo Activity of 5′-(E)- and 5′-(Z)-Vinylphosphonate-Modified siRNA Conjugates
Author:
Affiliation:
1. Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States
2. Department of Biochemistry and Center for Structural Biology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01147
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1. RNA interference and chemically modified small interfering RNAs
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4. The Race of 10 Synthetic RNAi-Based Drugs to the Pharmaceutical Market
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