BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer’s Disease-Reference-Cited by-同舟云学术

BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer’s Disease

Published:2017-08-08 Issue:3 Volume:61 Page:619-637
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Prati Federica¹,Bottegoni Giovanni²³^ORCID,Bolognesi Maria Laura⁴,Cavalli Andrea²⁴^ORCID

Affiliation:

1. Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, U.K.

2. CompuNet, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy

3. Heptares Therapeutics Ltd., BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, U.K.

4. Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy

Funder

Universit? di Bologna

Istituto Italiano di Tecnologia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00393

Reference115 articles.

1. Alzheimer's Disease: The Amyloid Cascade Hypothesis

2. Inconsistencies and controversies surrounding the Amyloid Hypothesis of Alzheimer¿s disease

3. The case for rejecting the amyloid cascade hypothesis

4. Ten Challenges of the Amyloid Hypothesis of Alzheimer’s Disease

5. Immunotherapy for Alzheimer’s disease: hoops and hurdles

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