Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2-Reference-Cited by-同舟云学术

Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2

Published:2017-08-01 Issue:15 Volume:60 Page:6704-6720
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Doornbos Maarten L. J.¹,Cid José María²,Haubrich Jordi¹,Nunes Alexandro¹,van de Sande Jasper W.¹,Vermond Sophie C.¹,Mulder-Krieger Thea¹,Trabanco Andrés A.²^ORCID,Ahnaou Abdellah³,Drinkenburg Wilhelmus H.³,Lavreysen Hilde³,Heitman Laura H.¹,IJzerman Adriaan P.¹^ORCID,Tresadern Gary²^ORCID

Affiliation:

1. Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300RA Leiden, The Netherlands

2. Janssen Research and Development, Calle Jarama 75A, 45007, Toledo, Spain

3. Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium

Funder

Vlaams Agentschap Innoveren & Ondernemen

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00669

Reference65 articles.

1. Ionotropic and metabotropic glutamate receptor structure and pharmacology