Synthesis and Biological Evaluation of (E)-4-Hydroxy-3-methylbut-2-enyl Phosphate (HMBP) Aryloxy Triester Phosphoramidate Prodrugs as Activators of Vγ9/Vδ2 T-Cell Immune Responses-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of (E)-4-Hydroxy-3-methylbut-2-enyl Phosphate (HMBP) Aryloxy Triester Phosphoramidate Prodrugs as Activators of Vγ9/Vδ2 T-Cell Immune Responses

Published:2018-02-19 Issue:5 Volume:61 Page:2111-2117
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Davey Martin S.^ORCID,Malde Roshni,Mykura Rory C.,Baker Alfie T.,Taher Taher E.,Le Duff Cécile S.,Willcox Benjamin E.^ORCID,Mehellou Youcef¹^ORCID

Affiliation:

1. School of Pharmacy and Pharmaceutical Sciences, Redwood Building, Cardiff University, Cardiff CF10 3NB, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01824

Reference31 articles.

1. Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire

2. Nonpeptide antigens, presentation mechanisms, and immunological memory of human Vγ2Vδ2 T cells: discriminating friend from foe through the recognition of prenyl pyrophosphate antigens

3. Adaptive Immune Response of Vγ2Vδ2 + T Cells During Mycobacterial Infections

4. γδ T cells for cancer immunotherapy

5. Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human γδ T cells inEscherichia coli

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