7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency

Author:

Goffin Eric1,Drapier Thomas1,Larsen Anja Probst2,Geubelle Pierre13,Ptak Christopher P.4ORCID,Laulumaa Saara2,Rovinskaja Karoline2,Gilissen Julie13,Tullio Pascal de1,Olsen Lars2ORCID,Frydenvang Karla2,Pirotte Bernard1,Hanson Julien13,Oswald Robert E.4,Kastrup Jette Sandholm2ORCID,Francotte Pierre1ORCID

Affiliation:

1. Laboratory of Medicinal Chemistry, Center for Interdisciplinary Research on Medicines (CIRM), University of Liège, Quartier Hôpital B36 Av. Hippocrate 15 B-4000 Liège, Belgium

2. Biostructural Research, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark

3. Laboratory of Molecular Pharmacology, GIGA-Molecular Biology of Diseases, University of Liège, Liège, Belgium

4. Department of Molecular Medicine, Cornell University, Ithaca, New York 14850, United States

Funder

National Institute of Neurological Disorders and Stroke

Universit? de Li?ge

Novo Nordisk

Det Frie Forskningsr?d

Fonds De La Recherche Scientifique - FNRS

National Institute of General Medical Sciences

Division of Materials Research

Lundbeckfonden

Danscatt

GluTarget

Fonds L?on Fr?d?ricq

CoNeXT

BioStructX

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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