Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs)

Author:

Previti Santo1ORCID,Ettari Roberta1ORCID,Cosconati Sandro2ORCID,Amendola Giorgio2ORCID,Chouchene Khawla3,Wagner Annika45,Hellmich Ute A.45,Ulrich Kathrin6ORCID,Krauth-Siegel R. Luise6,Wich Peter R.7ORCID,Schmid Ira7,Schirmeister Tanja7,Gut Jiri8,Rosenthal Philip J.8,Grasso Silvana1,Zappalà Maria1ORCID

Affiliation:

1. Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Annunziata, 98168 Messina, Italy

2. DiSTABiF, University of Campania Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy

3. Laboratoire de Chimie des Substances Naturelles UR/11-ES-74, Faculté des Sciences de Sfax, Université de Sfax, Route de l’aeroport, 3000 Sfax, Tunisia

4. Institute of Pharmacy and Biochemistry, University of Mainz, Johann-Joachim-Becherweg 30, DE 55128 Mainz, Germany

5. Centre for Biomolecular Magnetic Resonance (BMRZ), Goethe-University Frankfurt, Max-von-Laue-Strasse 9, DE 60438 Frankfurt am Main, Germany

6. Biochemistry Center, Heidelberg University, Im Neuenheimer Feld 328, DE 69120 Heidelberg, Germany

7. Institute of Pharmacy and Biochemistry, University of Mainz, Staudingerweg 5, DE 55128 Mainz, Germany

8. Department of Medicine, San Francisco General Hospital, University of California, 1001 Potrero Avenue, San Francisco, California 94110, United States

Funder

Carl-Zeiss-Stiftung

Universit? degli Studi di Messina

Zentrum f?r Biomolekulare Magnetische Resonanzspektroskopie, Goethe-Universit?t Frankfurt am Main

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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