Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists-Reference-Cited by-同舟云学术

Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists

Published:2018-02-06 Issue:6 Volume:61 Page:2518-2532
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lu Hongfu¹,Yang Ting¹,Xu Zhongmiao¹,Lin Xichen¹,Ding Qian¹,Zhang Yueting²,Cai Xin³,Dong Kelly³,Gong Sophie³,Zhang Wei³,Patel Metul⁴,Copley Royston C. B.⁵,Xiang Jianing¹,Guan Xiaoming¹,Wren Paul⁶,Ren Feng¹^ORCID

Affiliation:

1. Neurosciences Therapeutic Area Unit, GSK Pharmaceuticals R&D, 898 Halei Road, Zhangjiang Hi-Tech Park, Pudong, Shanghai 201203, P. R. China

2. R&D Projects Clinical Platforms and Sciences, GSK Pharmaceuticals R&D, 898 Halei Road, Zhangjiang Hi-Tech Park, Pudong, Shanghai 201203, P. R. China

3. Platform Technology Sciences, GSK Pharmaceuticals R&D, 898 Halei Road, Zhangjiang Hi-Tech Park, Pudong, Shanghai 201203, P. R. China

4. Platform Technology Sciences, GSK Pharmaceuticals R&D, Stevenage, Hertfordshire SG1 2NY, U.K.

5. Platform Technology & Science, GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

6. Neurosciences Therapeutic Area Unit, GSK Pharmaceuticals R&D, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01854

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