Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity

Author:

Heimburg Tino1,Kolbinger Fiona R.234,Zeyen Patrik1,Ghazy Ehab1,Herp Daniel5,Schmidtkunz Karin5,Melesina Jelena1,Shaik Tajith Baba6,Erdmann Frank1,Schmidt Matthias1,Romier Christophe6,Robaa Dina1,Witt Olaf2347,Oehme Ina234,Jung Manfred5ORCID,Sippl Wolfgang1ORCID

Affiliation:

1. Institute of Pharmacy, Martin-Luther University of Halle-Wittenberg, 06120 Halle/Saale, Germany

2. Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), INF 280, 69120 Heidelberg, Germany

3. German Consortium for Translational Cancer Research (DKTK), 69120 Heidelberg, Germany

4. Preclinical Program, Hopp Children’s Cancer Center at NCT Heidelberg (KiTZ), 69120 Heidelberg, Germany

5. Institute of Pharmaceutical Sciences, University of Freiburg, 79104 Freiburg, Germany

6. Département de Biologie Structurale Intégrative, Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UDS), CNRS, INSERM, 67404 Illkirch Cedex, France

7. Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg Medical Center, 69120 Heidelberg, Germany

Funder

Deutsche Forschungsgemeinschaft

Deutsche Krebshilfe

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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