Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase

Published:2018-05-04 Issue:12 Volume:61 Page:5162-5186
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Madak Joseph T.^ORCID,Cuthbertson Christine R.,Miyata Yoshinari,Tamura Shuzo,Petrunak Elyse M.¹,Stuckey Jeanne A.¹,Han Yanyan,He Miao,Sun Duxin,Showalter Hollis D.,Neamati Nouri^ORCID

Affiliation:

1. Life Sciences Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01862

Reference59 articles.

1. On Dihydroorotate Dehydrogenases and Their Inhibitors and Uses

2. Recent Developments in the Medicinal Chemistry and Therapeutic Potential of Dihydroorotate Dehydrogenase (DHODH) Inhibitors

3. Dihydroorotate dehydrogenase (DHODH) inhibitors affect ATP depletion, endogenous ROS and mediate S-phase arrest in breast cancer cells

4. The dihydroorotate dehydrogenases: Past and present

5. Use of human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors in Autoimmune Diseases and New Perspectives in Cancer Therapy

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