Design, Synthesis, and Biological Assessment of Biased Allosteric Modulation of the Urotensin II Receptor Using Achiral 1,3,4-Benzotriazepin-2-one Turn Mimics-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Assessment of Biased Allosteric Modulation of the Urotensin II Receptor Using Achiral 1,3,4-Benzotriazepin-2-one Turn Mimics

Published:2017-12-05 Issue:23 Volume:60 Page:9838-9859
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Douchez Antoine¹²^ORCID,Billard Etienne²,Hébert Terence E.³,Chatenet David²,Lubell William D.¹

Affiliation:

1. Département de Chimie, Université de Montréal, CP 6128, Station Centre-ville, Montréal, Québec H3C 3J7, Canada

2. INRS—Institut Armand-Frappier, Groupe de Recherche en Ingénierie des Peptides et en Pharmacothérapie (GRIPP), Université du Québec, Ville de Laval, Québec H7V 1B7, Canada

3. Department of Pharmacology and Therapeutics, McGill University, Montréal, Québec H3G 1Y6, Canada

Funder

Canadian Institutes of Health Research

Natural Sciences and Engineering Research Council of Canada

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01525

Reference74 articles.

1. Chemoselective Alkylation for Diversity-Oriented Synthesis of 1,3,4-Benzotriazepin-2-ones and Pyrrolo[1,2][1,3,4]benzotriazepin-6-ones, Potential Turn Surrogates