Affiliation:
1. Département de Chimie, Université de Montréal, Montréal, QC H2V 0B3, Canada
Abstract
Various benzotriazepine ring systems have been synthesized and examined for biological activity. Moreover, the 1,3,4-benzotriazepin-2-one has been shown to act as a constrained amino amide surrogate in mimics of peptide turn secondary structures. This review examines syntheses of the different benzotriazepine ring systems and heterocycle fused variants as well as their conformational and biological properties.
Funder
Institute of Health Services and Policy Research
Natural Sciences and Engineering Research Council of Canada
Fonds de recherche du Québec - Nature et technologies
Centre in Green Chemistry and Catalysis
Publisher
Canadian Science Publishing