Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells-Reference-Cited by-同舟云学术

Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells

Published:2017-06-27 Issue:13 Volume:60 Page:5800-5815
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ortega Jose Antonio¹,Arencibia Jose M.¹,La Sala Giuseppina¹,Borgogno Marco¹,Bauer Inga²,Bono Luca³,Braccia Clarissa³,Armirotti Andrea³,Girotto Stefania²,Ganesan Anand⁴,De Vivo Marco¹⁵^ORCID

Affiliation:

1. Laboratory of Molecular Modeling & Drug Discovery, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy

2. CompuNet, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy

3. D3-PharmaChemistry, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genoa, Italy

4. Department of Dermatology and Biological Chemistry, University of California, 202 Sprague Hall, 92697-2400 Irvine, United States

5. IAS-5/INM-9 Computational Biomedicine Forschungszentrum Jülich, Wilhelm-Johnen-Straße, 52428 Jülich, Germany

Funder

Associazione Italiana per la Ricerca sul Cancro

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00472

Reference51 articles.

1. Metastatic Melanoma – A Review of Current and Future Treatment Options

2. Global perspectives of contemporary epidemiological trends of cutaneous malignant melanoma

3. Palliative therapy of disseminated malignant melanoma: a systematic review of 41 randomised clinical trials

4. Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations

5. Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

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