Synthesis of benzimidazole/triphenylamine-based compounds, evaluation of their bioactivities and an in silico study with receptor tyrosine kinases

Author:

Arulkumar Mani1,Yang Kai12,Wang Neng1,Penislusshiyan Sakayanathan3,Palvannan Thayumanavan3,Ramalingam Karthick4,Chen Fuming4ORCID,Luo Shi-He1ORCID,Zhou Yong-Jun1,Wang Zhao-Yang1ORCID

Affiliation:

1. School of Chemistry, South China Normal University, Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, Guangzhou 510006, P. R. China

2. College of Pharmacy, Gannan Medical University, Ganzhou 341000, P. R. China

3. Laboratory of Bioprocess and Engineering, Department of Biochemistry, Periyar University, Salem 636 011, Tamil Nadu, India

4. Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials, Guangdong Provincial Engineering Technology Research Center for Wastewater Management and Treatment, School of Environment, School of Physics and Telecommunication Engineering, South China Normal University, Guangzhou 510006, P. R. China

Abstract

The antiproliferative activity of AL-1 against various cancer cells indicated the applicability of the BI-TPA-based compound as a potential multi-cancer inhibitor.

Funder

Education Department of Jiangxi Province

Guangdong Science and Technology Department

Ministry of Health and Family Welfare

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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