6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis-Reference-Cited by-同舟云学术

6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis

Published:2020-05-11 Issue:11 Volume:63 Page:6203-6224
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Salamoun Joseph M.¹,Garcia Christopher J.¹,Hargett Stefan R.²,Murray Jacob H.¹,Chen Sing-Young³,Beretta Martina³,Alexopoulos Stephanie J.³,Shah Divya P.³,Olzomer Ellen M.³,Tucker Simon P.⁴⁵,Hoehn Kyle L.²³,Santos Webster L.¹^ORCID

Affiliation:

1. Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, Virginia 24061, United States

2. Departments of Pharmacology and Medicine, University of Virginia, Charlottesville, Virginia 22908, United States

3. School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, NSW 2033, Australia

4. Continuum Biosciences, Pty Ltd., Sydney 2035, Australia

5. Continuum Biosciences Inc., Boston, Massachusetts 02116, United States

Funder

Virginia Biosciences Health Research Corporation

Continuum Biosciences, Inc.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00542

Reference93 articles.

1. Chemiosmotic coupling in oxidative and photosynthetic phosphorylation

2. The Double Life of ATP

3. REVERSIBLE INHIBITION OF THE COUPLING BETWEEN PHOSPHORYLATION AND OXIDATION

4. Mechanism of Action of Reagents that uncouple Oxidative Phosphorylation

5. Mitochondrial proton and electron leaks

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