Development of Novel AKR1C3 Inhibitors as New Potential Treatment for Castration-Resistant Prostate Cancer-Reference-Cited by-同舟云学术

Development of Novel AKR1C3 Inhibitors as New Potential Treatment for Castration-Resistant Prostate Cancer

Published:2020-08-27 Issue:18 Volume:63 Page:10396-10411
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Endo Satoshi¹^ORCID,Oguri Hiroaki¹,Segawa Jin¹,Kawai Mina¹,Hu Dawei²,Xia Shuang²,Okada Takuya²,Irie Katsumasa³⁴,Fujii Shinya⁵,Gouda Hiroaki⁶,Iguchi Kazuhiro⁷,Matsukawa Takuo⁸,Fujimoto Naohiro⁸,Nakayama Toshiyuki⁹,Toyooka Naoki²^ORCID,Matsunaga Toshiyuki¹⁰,Ikari Akira¹

Affiliation:

1. Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu 501-1196, Japan

2. Graduate School of Innovative Life Science, University of Toyama, Toyama 930-8555, Japan

3. Cellular and Structural Physiology Institute, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8601, Japan

4. Graduate School of Pharmaceutical Sciences, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8601, Japan

5. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo 101-0062, Japan

6. School of Pharmacy, Showa University, Tokyo 142-8555, Japan

7. Laboratory of Community Pharmacy, Department of Pharmacy, Gifu Pharmaceutical University, Gifu 501-1196, Japan

8. Department of Urology, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan

9. Department of Pathology, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan

10. Education Center of Green Pharmaceutical Sciences, Gifu Pharmaceutical University, Gifu 502-8585, Japan

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00939

Reference83 articles.

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2. Androgen Receptor Rediscovered: The New Biology and Targeting the Androgen Receptor Therapeutically

3. Increased androgen receptor transcription: a cause of castration-resistant prostate cancer and a possible therapeutic target

4. Molecular determinants of resistance to antiandrogen therapy

5. Androgen Receptor Mutations in Androgen-Independent Prostate Cancer: Cancer and Leukemia Group B Study 9663

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