Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer-Reference-Cited by-同舟云学术

Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer

Published:2021-10-03 Issue:19 Volume:64 Page:14192-14216
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Jin¹²,Zou Ling¹,Shi Danfeng¹³,Liu Jie¹,Zhang Jifa¹,Zhao Rongyan⁴,Wang Guan¹^ORCID,Zhang Lan⁴,Ouyang Liang¹^ORCID,Liu Bo¹^ORCID

Affiliation:

1. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China

2. School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen 518060, China

3. Warshel Institute for Computational Biology, School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen 518172, China

4. School of Life Science and Engineering, Southwest Jiaotong University Chengdu, Chengdu 610031, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Key Research and Development Program of Sichuan Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c02268

Reference60 articles.

1. Are sirtuins viable targets for improving healthspan and lifespan?

2. Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target

3. Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer

4. Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

5. Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

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