Synthesis, Structure–Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin-3 Inhibitors-Reference-Cited by-同舟云学术

Synthesis, Structure–Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin-3 Inhibitors

Published:2021-05-14 Issue:10 Volume:64 Page:6634-6655
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Xu Li¹^ORCID,Hartz Richard A.¹^ORCID,Beno Brett R.²,Ghosh Kaushik³^ORCID,Shukla Jinal K.³,Kumar Amit³,Patel Dipal⁴,Kalidindi Narasimharaju³,Lemos Nadine³,Gautam Shashyendra Singh³,Kumar Anoop³,Ellsworth Bruce A.¹^ORCID,Shah Devang³,Sale Harinath³,Cheng Dong⁵,Regueiro-Ren Alicia¹^ORCID

Affiliation:

1. Department of Small Molecule Drug Discovery, Bristol Myers Squibb Company, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543, United States

2. Department of Computer-Aided Drug Design & Molecular Analytics, Bristol Myers Squibb Company, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543, United States

3. Biocon-Bristol Myers Squibb Research and Development Center, Biocon Park, Plot No. 2 & 3, Bommasandra Phase IV, Jigani Link Road, Bangalore 560099, India

4. Department of Metabolism and Pharmacokinetics, Bristol Myers Squibb Company, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543, United States

5. Department of Cardiovascular and Fibrosis Discovery Biology, Bristol Myers Squibb Company, Research and Development, P.O. Box 5400, Princeton, New Jersey 08543, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c02001

Reference54 articles.

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4. Galectins at a glance

5. Inhibition and Detection of Galectins

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