Strong Binding of C-Glycosylic1,2-Thiodisaccharides to Galectin-3─Enthalpy-Driven Affinity Enhancement by Water-Mediated Hydrogen Bonds

Author:

Lázár László1,Tsagkarakou Anastasia S.2,Stravodimos George2,Kontopidis George3,Leffler Hakon4ORCID,Nilsson Ulf J.5ORCID,Somsák László1,Leonidas Demetres D.2ORCID

Affiliation:

1. Department of Organic Chemistry, University of Debrecen, P.O. Box 400, H-4002 Debrecen, Hungary

2. Department of Biochemistry and Biotechnology, University of Thessaly, Biopolis, 41500 Larissa, Greece

3. Department of Biochemistry, Veterinary School, University of Thessaly, 224 Trikalon, 43131 Karditsa, Greece

4. Department of Laboratory Medicine, Lund University, SE-2210 Lund, Sweden

5. Department of Chemistry, Lund University, SE-2210 Lund, Sweden

Funder

Centrum f?r idrottsforskning

National Research, Development and Innovation Office

European Cooperation in Science and Technology

European Social Fund

Greece

NSRF

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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