Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure–Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor-Reference-Cited by-同舟云学术

Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure–Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor

Published:2021-01-20 Issue:3 Volume:64 Page:1593-1610
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hoguet Vanessa¹,Lasalle Manuel¹,Maingot Mathieu¹,Dequirez Geoffroy¹,Boulahjar Rajaa¹,Leroux Florence²,Piveteau Catherine¹,Herledan Adrien¹,Biela Alexandre¹,Dumont Julie¹,Chávez-Talavera Oscar³,Belloy Loïc³,Duplan Isabelle³,Hennuyer Nathalie³,Butruille Laura³,Lestavel Sophie³,Sevin Emmanuel⁴,Culot Maxime⁴^ORCID,Gosselet Fabien⁴,Staels Bart³,Deprez Benoit²,Tailleux Anne³,Charton Julie²^ORCID

Affiliation:

1. Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000 Lille, France

2. Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, EGID, F-59000 Lille, France

3. Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000 Lille, France

4. Univ. Artois, UR 2465, Blood-brain barrier laboratory (LBHE), F-62300 Lens, France

Funder

Universit? de Lille

Agence Nationale de la Recherche

European Commission

European Regional Development Fund

H2020 European Research Council

SATT Nord

Conseil Re?gional Nord-Pas de Calais

Etat DRRT

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01774

Reference31 articles.

1. Effect of pegylation on pharmaceuticals

2. PEGylation, successful approach to drug delivery

3. Emerging PEGylated drugs

4. Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

5. PEG-modified biopharmaceuticals

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