Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue-Reference-Cited by-同舟云学术

Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue

Published:2020-04-24 Issue:10 Volume:63 Page:5458-5476
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ma Yao¹,Yin Dawei²,Ye Jingjia²,Wei Xiduan²,Pei Yameng²,Li Xueyuan²,Si Guangxu²,Chen Xuan-Yu³⁴,Chen Zhe-Sheng³,Dong Yi¹^ORCID,Zou Feng⁵,Shi Wei⁵,Qiu Qianqian⁵,Qian Hai⁵^ORCID,Liu Gang²^ORCID

Affiliation:

1. Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 2A Nanwei Road, Xicheng District, Beijing 100050, P. R. China

2. School of Pharmaceutical Sciences, Tsinghua University, Haidian District, Beijing 100084, P. R. China

3. College of Pharmacy and Health Science, St. John’s University, Queens, New York, New York 11439, United States

4. College of Integrated Chinese and Western Medicine, Hebei Medical University, Shijiazhuang, Hebei 050017, China

5. Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, P. R. China

Funder

National Natural Science Foundation of China

Non-profit Central Research Institute, Chinese Academy of Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00337

Reference44 articles.

1. Mechanisms of Multidrug Resistance in Cancer

2. The Emergence of Drug Transporter-Mediated Multidrug Resistance to Cancer Chemotherapy

3. Multi-drug resistance in cancer chemotherapeutics: Mechanisms and lab approaches

4. Drug resistance: Still a daunting challenge to the successful treatment of AML

5. A role for activator of G-protein signaling 3 (AGS3) in multiple myeloma

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