Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent Fragment-Based Approach-Reference-Cited by-同舟云学术

Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent Fragment-Based Approach

Published:2020-05-27 Issue:13 Volume:63 Page:7052-7065
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Huang Fubao¹²,Hu Hangchen³²⁴,Wang Kai¹²,Peng Chengyuan²,Xu Wenwei²,Zhang Yu²,Gao Jing³²,Liu Yishen⁵,Zhou Hu³²^ORCID,Huang Ruimin²,Li Minjun⁶,Shen Jianhua¹²^ORCID,Xu Yechun³²⁴^ORCID

Affiliation:

1. State Key Laboratory of Drug Research, Chinese Academy of Sciences, Shanghai 201203, China

2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

3. CAS Key Laboratory of Receptor Research, Chinese Academy of Sciences, Shanghai 201203, China

4. University of Chinese Academy of Sciences, Beijing 100049, China

5. Nanchang University, Nanchang 330031, China

6. Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201203, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00372

Reference58 articles.

1. Emerging and Re-Emerging Warheads for Targeted Covalent Inhibitors: Applications in Medicinal Chemistry and Chemical Biology

2. Structure-based design of targeted covalent inhibitors

3. Activity-based probes: discovering new biology and new drug targets

4. Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry

5. Arylfluorosulfate‐Based Electrophiles for Covalent Protein Labeling: A New Addition to the Arsenal

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