Rapid Optimization of the Metabolic Stability of a Human Immunodeficiency Virus Type-1 Capsid Inhibitor Using a Multistep Computational Workflow-Reference-Cited by-同舟云学术

Rapid Optimization of the Metabolic Stability of a Human Immunodeficiency Virus Type-1 Capsid Inhibitor Using a Multistep Computational Workflow

Published:2021-03-22 Issue:7 Volume:64 Page:3747-3766
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Meuser Megan E.¹^ORCID,Reddy Poli Adi Narayana²,Dick Alexej¹,Maurancy Jean Marc¹,Salvino Joseph M.²,Cocklin Simon¹^ORCID

Affiliation:

1. Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, Rooms 10307, 10309, and 10315, 245 North 15th Street, Philadelphia, Pennsylvania 19102, United States

2. The Wistar Cancer Center Molecular Screening, The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, United States

Funder

National Institute of Neurological Disorders and Stroke

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01810

Reference46 articles.

1. HIV-1 capsid: the multifaceted key player in HIV-1 infection

2. HIV-1 Assembly, Budding, and Maturation

3. Extreme Genetic Fragility of the HIV-1 Capsid

4. Structure, Function, and Interactions of the HIV-1 Capsid Protein

5. Image reconstructions of helical assemblies of the HIV-1 CA protein

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Application of an NMR/Crystallography Fragment Screening Platform for the Assessment and Rapid Discovery of New HIV‐CA Binding Fragments;ChemMedChem;2024-05-06

2. Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators;Journal of Medicinal Chemistry;2023-12-06

3. Application of an NMR/crystallography fragment screening platform for the assessment and rapid discovery of new HIV-CA binding fragments;2023-12-03

4. Computer-aided drug design in seeking viral capsid modulators;Drug Discovery Today;2023-06

5. Synthesis of Substituted Indazole Acetic Acids by N−N Bond Forming Reactions;European Journal of Organic Chemistry;2023-05-24