Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties-Reference-Cited by-同舟云学术

Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties

Published:2021-02-17 Issue:5 Volume:64 Page:2534-2575
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dragovich Peter S.¹^ORCID,Pillow Thomas H.¹,Blake Robert A.¹,Sadowsky Jack D.¹^ORCID,Adaligil Emel¹,Adhikari Pragya¹,Bhakta Sunil¹,Blaquiere Nicole¹,Chen Jinhua²,dela Cruz-Chuh Josefa¹,Gascoigne Karen E.¹,Hartman Steven J.¹,He Mingtao³,Kaufman Susan¹,Kleinheinz Tracy¹,Kozak Katherine R.¹,Liu Liang³,Liu Liling¹,Liu Qi³,Lu Ying²,Meng Fanwei³,Mulvihill Melinda M.¹,O’Donohue Aimee¹,Rowntree Rebecca K.¹,Staben Leanna R.¹,Staben Steven T.¹,Wai John²,Wang Jian²,Wei BinQing¹,Wilson Catherine¹,Xin Jianfeng³,Xu Zijin²,Yao Hui²,Zhang Donglu¹,Zhang Hongyan²,Zhou Hao²,Zhu Xiaoyu²

Affiliation:

1. Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China

3. Pharmaron Beijing, Co. Ltd., 6 Tai He Road, BDA, Beijing 100176, China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01845

Reference106 articles.

1. Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery