Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy-Reference-Cited by-同舟云学术

Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy

Published:2021-02-17 Issue:5 Volume:64 Page:2576-2607
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dragovich Peter S.¹^ORCID,Pillow Thomas H.¹,Blake Robert A.¹,Sadowsky Jack D.¹^ORCID,Adaligil Emel¹,Adhikari Pragya¹,Chen Jinhua²,Corr Nicholas¹,dela Cruz-Chuh Josefa¹,Del Rosario Geoffrey¹,Fullerton Aaron¹,Hartman Steven J.¹,Jiang Fan³,Kaufman Susan¹,Kleinheinz Tracy¹,Kozak Katherine R.¹,Liu Liling¹,Lu Ying²,Mulvihill Melinda M.¹,Murray Jeremy M.¹^ORCID,O’Donohue Aimee¹,Rowntree Rebecca K.¹,Sawyer William S.¹,Staben Leanna R.¹,Wai John²,Wang Jian²,Wei BinQing¹,Wei Wentao³,Xu Zijin²,Yao Hui²,Yu Shang-Fan¹,Zhang Donglu¹,Zhang Hongyan²,Zhang Shenhua³,Zhao Yongxin²,Zhou Hao²,Zhu Xiaoyu²

Affiliation:

1. Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China

3. Viva Biotech, Structural Biology, 334 Aidisheng Road, Zhangjiang High-Tech Park, Shanghai 201203, China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01846

Reference90 articles.

1. Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery