Acylated 1H-1,2,4-Triazol-5-amines Targeting Human Coagulation Factor XIIa and Thrombin: Conventional and Microscale Synthesis, Anticoagulant Properties, and Mechanism of Action

Author:

Korff Marvin1,Imberg Lukas1,Will Jonas M.2,Bückreiß Nico3,Kalinina Svetlana A.4ORCID,Wenzel Benjamin M.5,Kastner Gregor A.1,Daniliuc Constantin G.6ORCID,Barth Maximilian1,Ovsepyan Ruzanna A.78,Butov Kirill R.78ORCID,Humpf Hans-Ulrich4ORCID,Lehr Matthias1,Panteleev Mikhail A.79810,Poso Antti1112ORCID,Karst Uwe2ORCID,Steinmetzer Torsten5ORCID,Bendas Gerd3,Kalinin Dmitrii V.1ORCID

Affiliation:

1. Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Corrensstraße 48, 48149 Münster, Germany

2. Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstraße 30, 48149 Münster, Germany

3. Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany

4. Institute of Food Chemistry, University of Münster, Corrensstraße 45, 48149 Münster, Germany

5. Department of Pharmacy, Institute of Pharmaceutical Chemistry, Philipps University Marburg, Marbacher Weg 6, 35032 Marburg, Germany

6. Institute for Organic Chemistry, University of Münster, Corrensstraße 40, 48149 Münster, Germany

7. Laboratory of Translational Medicine, Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology, Samory Mashela str. 1, GSP-7, 117997 Moscow, Russia

8. Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, 4 Kosygina St, 119991 Moscow, Russia

9. Faculty of Physics, Lomonosov Moscow State University, 1/2 Leninskie gory, 119991 Moscow, Russia

10. Faculty of Biological and Medical Physics, Moscow Institute of Physics and Technology, 9 Institutskii per., 141700 Dolgoprudnyi, Russia

11. School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland

12. Department of Internal Medicine VIII, University Hospital Tübingen, 72076 Tübingen, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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