Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction-Reference-Cited by-同舟云学术

Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction

Published:2021-03-24 Issue:7 Volume:64 Page:4071-4088
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chessari Gianni¹^ORCID,Hardcastle Ian R.²^ORCID,Ahn Jong Sook¹,Anil Burcu³,Anscombe Elizabeth³,Bawn Ruth H.²,Bevan Luke D.¹,Blackburn Timothy J.²,Buck Ildiko¹,Cano Celine²^ORCID,Carbain Benoit²,Castro Juan¹,Cons Ben¹,Cully Sarah J.²,Endicott Jane A.⁴,Fazal Lynsey¹,Golding Bernard T.²,Griffin Roger J.²,Haggerty Karen²,Harnor Suzannah J.²^ORCID,Hearn Keisha¹,Hobson Stephen²,Holvey Rhian S.¹,Howard Steven¹,Jennings Claire E.⁴,Johnson Christopher N.¹^ORCID,Lunec John⁴,Miller Duncan C.²^ORCID,Newell David R.⁴,Noble Martin E. M.⁴,Reeks Judith¹,Revill Charlotte H.²,Riedinger Christiane³,St. Denis Jeffrey D.¹,Tamanini Emiliano¹^ORCID,Thomas Huw⁴,Thompson Neil T.¹,Vinković Mladen¹,Wedge Stephen R.⁴,Williams Pamela A.¹,Wilsher Nicola E.¹,Zhang Bian²,Zhao Yan⁴

Affiliation:

1. Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K.

2. Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K.

3. Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.

4. Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Paul O’Gorman Building, Newcastle upon Tyne NE2 4HH, U.K.

Funder

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c02188

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