Modulation of the Passive Permeability of Semipeptidic Macrocycles: N- and C-Methylations Fine-Tune Conformation and Properties-Reference-Cited by-同舟云学术

Modulation of the Passive Permeability of Semipeptidic Macrocycles: N- and C-Methylations Fine-Tune Conformation and Properties

Published:2021-03-22 Issue:9 Volume:64 Page:5365-5383
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Comeau Christian¹,Ries Benjamin²^ORCID,Stadelmann Thomas²^ORCID,Tremblay Jacob¹,Poulet Sylvain¹,Fröhlich Ulrike¹,Côté Jérôme¹,Boudreault Pierre-Luc¹,Derbali Rabeb Mouna³,Sarret Philippe¹^ORCID,Grandbois Michel¹,Leclair Grégoire³,Riniker Sereina²^ORCID,Marsault Éric¹^ORCID

Affiliation:

1. Département de Pharmacologie−Physiologie, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, 3001, 12e av nord, Sherbrooke, Quebec, Canada J1H5N4

2. Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 2, 8093 Zürich, Switzerland

3. Faculté de pharmacie, Université de Montréal, C.P. 6128, succursale Centre-ville, Montréal, Quebec, Canada H3C 3J7

Funder

Eidgen?ssische Technische Hochschule Z?rich

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Canada Foundation for Innovation

Natural Sciences and Engineering Research Council of Canada

Centre des Neurosciences de Sherbrooke

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine