Discovery of Clinical Candidate (5-(3-(4-Chlorophenoxy)prop-1-yn-1-yl)-3-hydroxypicolinoyl)glycine, an Orally Bioavailable Prolyl Hydroxylase Inhibitor for the Treatment of Anemia-Reference-Cited by-同舟云学术

Discovery of Clinical Candidate (5-(3-(4-Chlorophenoxy)prop-1-yn-1-yl)-3-hydroxypicolinoyl)glycine, an Orally Bioavailable Prolyl Hydroxylase Inhibitor for the Treatment of Anemia

Published:2020-07-28 Issue:17 Volume:63 Page:10045-10060
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Xiaojin¹²^ORCID,Lei Yonghua¹³,Hu Tianhan¹³,Wu Yue¹³,Li Zhihong²^ORCID,Jiang Zhensheng¹³,Yang Changyong⁴,Zhang Lianshan⁴,You Qidong¹³^ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China

2. Department of Chemistry, China Pharmaceutical University, Nanjing 211198, China

3. Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China

4. Shanghai Hengrui Pharmaceutical Co., Ltd., Shanghai 200245, China

Funder

Ministry of Science and Technology of the People's Republic of China

State Key Laboratory of Natural Medicines

Government of Jiangsu Province

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine