Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion
Author:
Affiliation:
1. Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States
2. Viva Biotech, Shanghai 201203, China
3. ChemPartner, Shanghai 201203, China
Funder
Agios Pharmaceuticals
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01895
Reference35 articles.
1. Amplified and Homozygously Deleted Genes in Glioblastoma: Impact on Gene Expression Levels
2. MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis
3. Concordant Loss of MTAP and p16/CDKN2A Expression in Gastroesophageal Carcinogenesis
4. Codeletion of the genes for p16INK4, methylthioadenosine phosphorylase, interferon-α1, interferon-β1, and other 9p21 markers in human malignant cell lines
5. MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
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