Small Molecule Inhibitors Targeting Biosynthesis of Ceramide, the Central Hub of the Sphingolipid Network-Reference-Cited by-同舟云学术

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Small Molecule Inhibitors Targeting Biosynthesis of Ceramide, the Central Hub of the Sphingolipid Network

Published:2021-01-04 Issue:1 Volume:64 Page:279-297
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Skácel Jan,Slusher Barbara S.^ORCID,Tsukamoto Takashi^ORCID

Funder

Alzheimer's Association

Rainwater Charitable Foundation

National Institute on Aging

National Institute of Mental Health

Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01664

Reference163 articles.

1. A comprehensive classification system for lipids

2. The long and the short of ceramides

3. An Overview of Sphingolipid Metabolism: From Synthesis to Breakdown

4. Ceramide Synthases: Roles in Cell Physiology and Signaling

5. Ceramide synthesis and metabolism as a target for cancer therapy

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1. The relationship between sphingomyelin and ceramide levels and soft neurological signs in ADHD;Journal of Neural Transmission;2024-09-09

2. A Cyclometalated Iridium(III) Complex Exerts High Anticancer Efficacy via Fatty Acid Beta-Oxidation Inhibition and Sphingolipid Metabolism Reprogramming;Journal of Medicinal Chemistry;2024-09-03

3. The sphingosine kinase 2 inhibitors ABC294640 and K145 elevate (dihydro)sphingosine 1-phosphate levels in various cells;Journal of Lipid Research;2024-08

4. Discovery of a Novel ASM Direct Inhibitor with a 1,5-Diphenyl-pyrazole Scaffold and Its Antidepressant Mechanism of Action;Journal of Medicinal Chemistry;2024-06-18

5. Roles and therapeutic targeting of ceramide metabolism in cancer;Molecular Metabolism;2024-05

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