A Cyclometalated Iridium(III) Complex Exerts High Anticancer Efficacy via Fatty Acid Beta-Oxidation Inhibition and Sphingolipid Metabolism Reprogramming

Author:

Lin Cuiyan12,Wang Huiling12,Chen Keyu2,Liu Shuangqiang2,Mao Zhichen2,Mo Zuyu23,Huang Rizhen2,Zhang Ye2,Xie Wei4,Wei Jianhua1423ORCID,Jin Junfei14567

Affiliation:

1. Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, The Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, China

2. Guangxi Key Laboratory of Drug Discovery and Optimization, Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, Key Laboratory of Medical Biotechnology and Translational Medicine, School of Pharmacy, Guilin Medical University, Guilin, Guangxi 541199, China

3. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China

4. Key Laboratory of Developmental Genes and Human Disease, School of Life Science and Technology, Southeast University, Nanjing 210096, China

5. Guangxi Health Commission Key Laboratory of Basic Research in Sphingolipid Metabolism Related Diseases, The Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, China

6. China-USA Lipids in Health and Disease Research Center, Guilin Medical University, Guilin, Guangxi 541001, China

7. Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, China

Funder

Guilin Science and Technology Bureau

Natural Science Foundation of Guangxi Zhuang Autonomous Region

Guilin Medical University

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Education

National Natural Science Foundation of China

Science and Technology Department of Guangxi Zhuang Autonomous Region

Guangxi Medical and Health Key Discipline Construction Project

Lijiang Scholar Award in Guilin

Medical High Level Talents Training Plan in Guangxi

Publisher

American Chemical Society (ACS)

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