Diazaspirononane Nonsaccharide Inhibitors of O-GlcNAcase (OGA) for the Treatment of Neurodegenerative Disorders-Reference-Cited by-同舟云学术

Diazaspirononane Nonsaccharide Inhibitors of O-GlcNAcase (OGA) for the Treatment of Neurodegenerative Disorders

Published:2020-11-16 Issue:22 Volume:63 Page:14017-14044
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Martínez-Viturro Carlos M.¹^ORCID,Trabanco Andrés A.¹^ORCID,Royes Jordi²^ORCID,Fernández Elena²^ORCID,Tresadern Gary³^ORCID,Vega Juan A.¹,del Cerro Alcira¹,Delgado Francisca¹,García Molina Aránzazu¹,Tovar Fulgencio⁴,Shaffer Paul⁵,Ebneth Andreas⁶,Bretteville Alexis⁶,Mertens Liesbeth⁶,Somers Marijke⁷,Alonso Jose M.⁸,Bartolomé-Nebreda José M.¹

Affiliation:

1. Discovery Chemistry, Janssen Research & Development, Janssen-Cilag S.A., C/Jarama 75A, 45007 Toledo, Spain

2. Department Química Física i Inorgànica, University Rovira i Virgili, C/Marcel·lí Domingo s/n, 43007 Tarragona, Spain

3. Computational Chemistry, Janssen Research & Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, 2440 Beerse, Belgium

4. Villapharma Research S.L., Parque Tecnológico de Fuente Álamo, Ctra. El Estrecho-Lobosillo, Km. 2.5—Av. Azul, 30320 Fuente Álamo de Murcia, Spain

5. X-Ray Crystallography, Janssen Pharmaceutical Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477, United States

6. Neuroscience Discovery, Janssen Research & Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, 2440 Beerse, Belgium

7. Discovery DMPK, Janssen Research & Development, Janssen Pharmaceutica NV, Turnhoutseweg 30, 2440 Beerse, Belgium

8. Analytical Sciences, Janssen Research & Development, Janssen-Cilag, S.A., C/Jarama 75A, 45007 Toledo, Spain

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01479

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