Validating the 1,2-Difluoro Motif As a Hybrid Bioisostere of CF3 and Et Using Matrix Metalloproteinases As Structural Probes

Author:

Erdeljac Nathalie1,Thiehoff Christian1,Jumde Ravindra P.2,Daniliuc Constantin G.1,Höppner Sandra3,Faust Andreas3,Hirsch Anna K. H.24ORCID,Gilmour Ryan1ORCID

Affiliation:

1. Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149 Münster, Germany

2. Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) – Helmholtz Centre for Infection Research (HZI), University Campus E8.1, 66123 Saarbrücken, Germany

3. European Institute for Molecular Imaging, Westfälische Wilhelms-Universität Münster, Waldeyerstraße 15, 48149 Münster, Germany

4. Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany

Funder

Westf?lische Wilhelms-Universit?t M?nster

Deutsche Forschungsgemeinschaft

H2020 Marie Sklodowska-Curie Actions

Helmholtz Association

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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