Validating the 1,2-Difluoro Motif As a Hybrid Bioisostere of CF3 and Et Using Matrix Metalloproteinases As Structural Probes-Reference-Cited by-同舟云学术

Validating the 1,2-Difluoro Motif As a Hybrid Bioisostere of CF3 and Et Using Matrix Metalloproteinases As Structural Probes

Published:2020-05-07 Issue:11 Volume:63 Page:6225-6237
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Erdeljac Nathalie¹,Thiehoff Christian¹,Jumde Ravindra P.²,Daniliuc Constantin G.¹,Höppner Sandra³,Faust Andreas³,Hirsch Anna K. H.²⁴^ORCID,Gilmour Ryan¹^ORCID

Affiliation:

1. Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149 Münster, Germany

2. Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) – Helmholtz Centre for Infection Research (HZI), University Campus E8.1, 66123 Saarbrücken, Germany

3. European Institute for Molecular Imaging, Westfälische Wilhelms-Universität Münster, Waldeyerstraße 15, 48149 Münster, Germany

4. Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany

Funder

Westf?lische Wilhelms-Universit?t M?nster

Deutsche Forschungsgemeinschaft

H2020 Marie Sklodowska-Curie Actions

Helmholtz Association

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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