Aminoalkoxycarbonyloxymethyl Ether Prodrugs with a pH-Triggered Release Mechanism: A Case Study Improving the Solubility, Bioavailability, and Efficacy of Antimalarial 4(1H)-Quinolones with Single Dose Cures-Reference-Cited by-同舟云学术

Aminoalkoxycarbonyloxymethyl Ether Prodrugs with a pH-Triggered Release Mechanism: A Case Study Improving the Solubility, Bioavailability, and Efficacy of Antimalarial 4(1H)-Quinolones with Single Dose Cures

Published:2021-05-12 Issue:10 Volume:64 Page:6581-6595
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Monastyrskyi Andrii¹,Brockmeyer Fabian²,LaCrue Alexis N.³,Zhao Yingzhao²,Maher Steven P.⁴,Maignan Jordany R.¹,Padin-Irizarry Vivian⁵⁴,Sakhno Yana I.¹,Parvatkar Prakash T.²,Asakawa Ami H.⁶,Huang Lili²,Casandra Debora³,Mashkouri Sherwin³,Kyle Dennis E.³⁴,Manetsch Roman¹²⁶

Affiliation:

1. Department of Chemistry, University of South Florida, CHE 205, 4202 E. Fowler Avenue, Tampa, Florida 33620, United States

2. Department of Chemistry and Chemical Biology, Northeastern University, 360 Huntington Avenue, 102 Hurtig Hall, Boston, Massachusetts 02115, United States

3. Department of Global Health, College of Public Health, University of South Florida, 3720 Spectrum Blvd, Suite 304, Tampa, Florida 33612, United States

4. Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Coverdell Center, Rm 370B, 500 DW Brooks Drive, Athens, Georgia 30602, United States

5. Department of Biology, Clayton State University, 2000 Clayton State Boulevard, Morrow, Georgia 30260, United States

6. Department of Pharmaceutical Sciences, Northeastern University, 102 Hurtig Hall, 360 Huntington Avenue, Boston, Massachusetts 02115, United States

Funder

National Institute of Allergy and Infectious Diseases

Medicines for Malaria Venture

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01104

Reference48 articles.

1. Bridging solubility between drug discovery and development

2. Drug-Like Property Concepts in Pharmaceutical Design

3. Prodrugs—from Serendipity to Rational Design

4. Prodrugs: design and clinical applications

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