Discovery of (S)-2-(1-(4-Amino-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propyl)-3-cyclopropyl-5-fluoroquinazolin-4(3H)-one (IHMT-PI3Kδ-372) as a Potent and Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease-Reference-Cited by-同舟云学术

Discovery of (S)-2-(1-(4-Amino-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propyl)-3-cyclopropyl-5-fluoroquinazolin-4(3H)-one (IHMT-PI3Kδ-372) as a Potent and Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease

Published:2020-11-12 Issue:22 Volume:63 Page:13973-13993
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Feng¹²,Liang Xiaofei¹³^ORCID,Jiang Zongru¹³,Wang Aoli¹³,Wang Junjie¹²,Chen Cheng¹²,Wang Wenliang¹²,Zou Fengming¹³,Qi Ziping¹³,Liu Qingwang¹³,Hu Zhenquan¹,Cao Jiangyan¹²,Wu Hong¹³,Wang Beilei¹³,Wang Li¹³,Liu Jing¹³⁴^ORCID,Liu Qingsong¹²³⁴⁵^ORCID

Affiliation:

1. Anhui Province Key Laboratory of Medical Physics and Technology; CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology; Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, P. R. China

2. University of Science and Technology of China, Hefei, Anhui 230026, P. R. China

3. Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui 230031, P. R. China

4. Precision Medicine Research Laboratory of Anhui Province, Hefei, Anhui 230088, P. R. China

5. Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui 230601, P. R. China

Funder

Hefei Institutes of Physical Science, Chinese Academy of Sciences

National Natural Science Foundation of China

Department of S and T for Social Development

Natural Science Foundation of Anhui Province

Chinese Academy of Sciences

University Synergy Innovation Program of Anhui Province

Postdoctoral Science Foundation of Anhui Province