Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype-Reference-Cited by-同舟云学术

Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype

Published:2021-02-12 Issue:5 Volume:64 Page:2691-2704
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Olaoye Olasunkanmi O.¹²,Watson Paris R.³,Nawar Nabanita¹²,Geletu Mulu¹,Sedighi Abootaleb¹^ORCID,Bukhari Shazreh¹²,Raouf Yasir S.¹²,Manaswiyoungkul Pimyupa¹²,Erdogan Fettah¹²,Abdeldayem Ayah¹²,Cabral Aaron D.¹²,Hassan Muhammad Murtaza¹²,Toutah Krimo¹,Shouksmith Andrew E.¹,Gawel Justyna M.¹,Israelian Johan¹²,Radu Tudor B.¹²,Kachhiyapatel Niyati¹,de Araujo Elvin D.¹,Christianson David W.³^ORCID,Gunning Patrick T.¹²^ORCID

Affiliation:

1. Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Rd N., Mississauga, Ontario L5L 1C6, Canada

2. Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada

3. Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States

Funder

Canadian Institutes of Health Research

Canada Research Chairs

U.S. Department of Energy

Natural Sciences and Engineering Research Council of Canada

National Institute of General Medical Sciences

Canadian Breast Cancer Foundation

Canadian Cancer Society

Jesse's Journey

Ontario Research Fund

Publisher

American Chemical Society (ACS)