Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase-Reference-Cited by-同舟云学术

Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase

Published:2021-02-16 Issue:4 Volume:64 Page:1889-1903
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Markert Christian^ORCID,Thoma Gebhard,Srinivas Honnappa,Bollbuck Birgit,Lüönd Rainer M.,Miltz Wolfgang,Wälchli Rudolf,Wolf Romain,Hinrichs Jürgen,Bergsdorf Christian,Azzaoui Kamal,Penno Carlos A.,Klein Kai,Wack Nathalie,Jäger Petra,Hasler Franziska,Beerli Christian,Loetscher Pius,Dawson Janet^ORCID,Wieczorek Grazyna,Numao Shin^ORCID,Littlewood-Evans Amanda,Röhn Till A.

Funder

Novartis Institutes for BioMedical Research Inc.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01955

Reference39 articles.

1. Leukotrien A4 hydrolase and the committed step in leukotriene B4 biosynthesis

2. Opioid peptides are substrates for the bifunctional enzyme LTA4 hydrolase/aminopeptidase

3. Characterization of the aminopeptidase activity of epidermal leukotriene A4 hydrolase against the opioid dynorphin fragment 1-7