Discovery and Biological Evaluation of N-Methyl-pyrrolo[2,3-b]pyridine-5-carboxamide Derivatives as JAK1-Selective Inhibitors-Reference-Cited by-同舟云学术

Discovery and Biological Evaluation of N-Methyl-pyrrolo[2,3-b]pyridine-5-carboxamide Derivatives as JAK1-Selective Inhibitors

Published:2021-01-11 Issue:2 Volume:64 Page:958-979
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Park Eunsun¹,Lee Sun Joo²,Moon Heegyum²,Park Jongmi¹,Jeon Hyeonho²,Hwang Ji Sun²,Hwang Hayoung²,Hong Ki Bum²^ORCID,Han Seung-Hee³,Choi Sun¹^ORCID,Kang Soosung¹^ORCID

Affiliation:

1. College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea

2. New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Republic of Korea

3. Central Research Laboratory, KOREA PHARMA Co. Ltd, jeyakgongdan 3-gil, Hyangnam-eup, Hwaseong-si, Gyeonggi-do 18622, Republic of Korea

Funder

National Research Foundation of Korea

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c01026

Reference42 articles.

1. JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

2. The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

3. The Janus kinases (Jaks)

4. JAK–STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects

5. JAK inhibition using tofacitinib for inflammatory bowel disease treatment: a hub for multiple inflammatory cytokines

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