Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action-Reference-Cited by-同舟云学术

Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action

Published:2020-06-10 Issue:13 Volume:63 Page:7422-7444
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bonardi Alessandro¹²,Nocentini Alessio¹²^ORCID,Bua Silvia¹,Combs Jacob³,Lomelino Carrie³^ORCID,Andring Jacob³^ORCID,Lucarini Laura⁴,Sgambellone Silvia⁴,Masini Emanuela⁴,McKenna Robert³,Gratteri Paola¹²^ORCID,Supuran Claudiu T.¹^ORCID

Affiliation:

1. Department NEUROFARBA − Pharmaceutical and nutraceutical section, University of Firenze, via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence Italy

2. Department NEUROFARBA − Pharmaceutical and nutraceutical section; Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Firenze, via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy

3. Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Box 100245, Gainesville, Florida 32610, United States

4. Department NEUROFARBA − Pharmaceutical and nutraceutical section, University of Firenze, viale Gaetano Pieraccini 6, 50139 Firenze, Florence, Italy

Funder

Ministero dell?Istruzione, dell?Universit? e della Ricerca

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c00733

Reference70 articles.

1. Carbonic anhydrase: chemistry, physiology, and inhibition

2. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

3. The γ class of carbonic anhydrases