Harnessing Nitric Oxide-Donating Benzofuroxans for Targeted Inhibition of Carbonic Anhydrase IX in Cancer-Reference-Cited by-同舟云学术

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Harnessing Nitric Oxide-Donating Benzofuroxans for Targeted Inhibition of Carbonic Anhydrase IX in Cancer

Published:2024-08-29 Issue:17 Volume:67 Page:15892-15907
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bua Silvia¹,Nocentini Alessio¹^ORCID,Bonardi Alessandro¹,Palma Giuseppe²,Ciampi Giulia³,Giliberti Angela³,Iannelli Federica⁴,Bruzzese Francesca²,Supuran Claudiu T.¹^ORCID,de Nigris Filomena³

Affiliation:

1. NEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, 50019 Sesto Fiorentino, Firenze Italy

2. Experimental Animal Unit, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli 80131, Italy

3. Department of Precision Medicine, School of Medicine, University of Campania “Luigi Vanvitelli″, Napoli 80138, Italy

4. Experimental Pharmacology Unit, Istituto Nazionale Tumori − IRCCS -Fondazione G. Pascale, Napoli 80131, Italy

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01563

Reference57 articles.

1. Interfering with pH regulation in tumours as a therapeutic strategy

2. Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells

3. Acidic pH enhances the invasive behavior of human melanoma cells

4. Acid treatment of melanoma cells selects for invasive phenotypes

5. Acidity Generated by the Tumor Microenvironment Drives Local Invasion

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