Novel Electrophilic Warhead Targeting a Triple-Negative Breast Cancer Driver in Live Cells Revealed by “Inverse Drug Discovery”-Reference-Cited by-同舟云学术

Novel Electrophilic Warhead Targeting a Triple-Negative Breast Cancer Driver in Live Cells Revealed by “Inverse Drug Discovery”

Published:2021-10-08 Issue:21 Volume:64 Page:15582-15592
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Fan Youlong¹,Si Hongfei¹,Zhang Zhang¹,Zhong Liang¹,Sun Hongyan²^ORCID,Zhu Chengjun¹,Yin Zhibin³,Li Huilin³^ORCID,Tang Guanghui⁴,Yao Shao Q.⁴^ORCID,Sun Pinghua¹,Zhang Zhi-Min¹,Ding Ke¹^ORCID,Li Zhengqiu¹^ORCID

Affiliation:

1. School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China

2. Department of Chemistry, City University of Hong Kong, Hong Kong 999077, China

3. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China

4. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore

Funder

Ministry of Science and Technology of the People's Republic of China

National Research Foundation Singapore

National Natural Science Foundation of China

Science and Technology Program of Guangdong Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.0c02024

Reference39 articles.

1. Triple-Negative Breast Cancer

2. A Review of Systemic Treatment in Metastatic Triple-Negative Breast Cancer

3. The resurgence of covalent drugs

4. The Cysteinome of Protein Kinases as a Target in Drug Development

5. Synthetic Approaches to New Drugs Approved during 2018

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